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Genomic and proteomic analyses of transgenic animal models..55. Concern about health and welfare Applications of RNAi in animal biotechnology ..57 . Gene therapy for mucopolysaccharidosis VII in dogs 142

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May 25, 2006 results for the drug in animal models, according to its founders Like gene therapy, RNAi is a powerful technology with great

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A normal adult Drosophila fly, a common model organism used in RNAi experiments. .. "Animal virus replication and RNAi-mediated antiviral silencing in .. " RNAi Gene Therapy to Control HIV-1 Infection". RNA Interference and

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by M Takanashi - 2009 - Cited by 5 - Related articlesMay 28, 2009 of the siRNA cream on larger animal models yet because .. expression in a murine wound model. Gene Therapy 2007; 14: 1305–1308.

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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by F Takeshita - 2006 - Cited by 62 - Related articleshave investigated siRNA in animal models. Studies on the .. Intravenous RNA interference gene therapy targeting the human

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Large Animal Models in Gene Therapy Preclinical Studies. Workshop 212 9:30 am - 11:00 am Delivery of Oligo/RNAi to Respiratory Cells - Where do they go?

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by R Rivas - Related articlespreviously associated with gene therapy, have taken these lessons to heart and learned from some of Animal models have shown that the absence of this protein is not harmful, interference (RNAi) has potential for the treatment

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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by GL Størvold - 2006 - Cited by 8 - Related articlesDNA and RNA for gene therapy, and extensive efforts are now placed into an in vitro system to inhibit metastasis in an animal model.132133 Adhesion

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by X Zheng - 2010 - Related articlessiRNA design and gene transfection. siRNA sequence (TGTTCCACTGGGCTGAGAA) .. This therapy is highly effective in mouse models [4,18], although the overall while CII is sufficient to induce an RA-like disease in animal models,

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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by LS Reddy - 2007 - Cited by 1 - Related articleswith the first in vivo animal models for HCV infection atherosclerosis is the up -regulation of cell . PEPCK for diabetes gene therapy. RNAi holds promise

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by SD Buckingham - 2004 - Cited by 48 - Related articlesRNAi is now the most potent gene knockdown method used in animal systems. Preliminary investigations of RNAi as a therapy using model organisms have

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Animal models: in vivo-jetPEI™ was successfully used to deliver nucleic acids to a wide Nickerson H. D and Colledge W. H. (2004) , Gene Ther. 11; 1351

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Moreover, appropriate animal models exist in which to carry out the necessary . (2006) RNA interference for antiviral therapy. J Gene Med 8: 933-950

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Dec 15, 2005 Beginning in 2003 genOway launched its Safe RNAi Transgenesis™ . During the 1990s great interest for gene therapy emerged for the first time. animal models and offers a full range of solutions for both gene

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by KK Jain - 2006 - Cited by 10 - Related articlesRNAi to animal models to suppress disease genes and correct disease pheno- types . One of the biggest hurdles in. RNAi-based therapy is delivery. Even if

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Aug 28, 2006 But work in animal models should go in parallel. Right now, virus-mediated gene therapy appears to be the obvious way, but there is a

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18, 2007 RNAi shows promise in gene therapy, Stanford researcher says. test them in the appropriate animal models, uncover the mechanisms involved in

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by T Note - Related articlesin animal disease models.1 In vivo RNAi also has the potential to be used as siRNA therapeutics . Gene Therapy 12 (2005): 59-66. 9. Minakuchi, Y., et al.

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by RKM Leung - 2005 - Cited by 195 - Related articlesthe knockdown of gene expression in experimental animals, with the development of shRNA RNA interference: from model organisms towards therapy for

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by SQ Harper - 2005 - Cited by 227 - Related articles*Program in Gene Therapy, Departments of †Internal Medicine, §Neurology, .. that RNAi can improve neuropathology and behavioral deficits in a mouse model

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by SI Nakagawa - 2005RNA interference (RNAi) is a gene-silencing mechanism mediated by small interfering when administered intravenously in a mouse model of liver metastasis. complex is expected to provide a novel RNAi therapy for cancer patients.

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by SK Lee - 2009 - Cited by 2 - Related articlesConditional RNAi: Towards a silent gene therapy star, open .. Many have been used to develop therapeutically-relevant animal models that allow spatial

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This discovery allowed the development of cell lines and animal models with .. The RNAi therapy would be delivered to the central nervous system by

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by B Berkhout - 2009 - Cited by 6 - Related articlesApr 1, 2010 For the development of an effective RNAi gene therapy, . addressed in appropriate animal models before clinical trials can be considered.

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by M Ebbesen - 2010 - Cited by 1 - Related articlesThese involve studies in test tubes, cell cultures and animal models to .. Racz Z, Hamar P. Can siRNA technology provide the tools for gene therapy of

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Stem cell-based gene therapy and RNAi for sickle cell disease131. Gene therapy for ? . Animal models for gene therapy of arteriovenous malformations288

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by A Jagannath - 2007 - Cited by 4 - Related articlesRNAi has shown therapeutic value in vitro and in animal disease models and clinical trials Keywords: RNA interference, siRNA, microRNA, gene therapy,

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To date RNAi based gene inhibition to identify potential new drug targets has viable nanoparticles for tissue targeted delivery for RNAi, gene therapy, Translation of RNAi from cell culture to in vivo animal models of cancer

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The Harper lab utilizes a broad range of tools, including molecular biology, biochemistry, RNAi, gene therapy vectors, and animal models for muscular

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See more headlines about genomics and gene therapy. Longevity Assurance Genes, Caloric Restriction, Animal models of aging, Stem Cells

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by N Durcan - 2008 - Cited by 30 - Related articles(22) Adenovirus vectors have been demonstrated to mediate gene silencing in an in vitro lung model(23) and to induce RNAi in a range of animal tissues.(24)

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HD researchers called the idea of using gene therapy to cure HD 'science siRNA Helps a Viral Transgenic Mouse Model of HD. RNA interference using a

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Apr 29, 2009 The macrophages carrying the RNAi moved throughout the organism as they circulated as a drug delivery system has been tested in a number of animal models. The RNA drug revolution -- a new approach to gene therapy

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The study demonstrated that neither animal behaviour nor brain structures were affected by RNA interference gene therapy. Davidson said: "As yet,

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proved not only in cell culture but also in in vivo major disease-related animal models. RNAi as a New Kind of Gene Therapy:Therapeutic Potential

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by PA Marsden - 2006 - Cited by 25 - Related articlesAug 31, 2006 Several animal models of human disease have been successfully treated with to exogenous shRNA derived from viral gene-therapy vectors.

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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by IS Blagbrough - 2009 - Cited by 5 - Related articlesmetabolism. Thus, there are many excellent animal models available to investigate target diseases using the new technol- ogies of gene therapy and RNAi.

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May 24, 2006 That finding kicked off an RNAi gene therapy research flurry amongst Cells in Animal Model, Stanford Study Finds · Gene Therapy Beats

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by H Paulson - 2006 - Cited by 10 - Related articlesGene therapy approaches have been attempted in the muscles for years, ranging from . RNAi suppression of neurodegeneration in a mouse model of SCA1.

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May 24, 2010 Translation of RNAi from cell culture to in vivo animal models of . Gene Therapy Plus Chemotherapy Ups Odds for Success in Treating

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May 15, 2006 in many cell-culture systems and preclinical animal models. New 'Holy Grail' of gene-silencing technology RNAi cancer therapies set for clinical testing Biochips help reduce the need for animal testing

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by SI Pai - 2005 - Cited by 108 - Related articlesRNAi therapy targeting gene products involved in tumor–host interactions . tumorigenesis of a breast cancer cell line in an animal model.103 Thus,

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by MS Weinberg - 2010Apr 28, 2010 Antiviral Gene Therapy Research Unit, Department of Molecular .. The progress made in the field of RNAi-based HBV therapy has been impressive. and despite the limited availability of suitable animal models of HBV

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by MM Maxwell - 2009 - Cited by 2 - Related articles of specific genes, this approach holds great promise as a therapy for diverse to probe disease-associated pathways in both cell-based and animal models, It further describes current applications of RNAi techniques for target

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Jun 3, 2010 Stem cell-based gene therapy and RNAi for sickle cell disease131 . Animal models for gene therapy of arteriovenous malformations288

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by AI Med - 2005Many of the challenges of RNAi are the same as those of gene therapy: to co- opt for learning about cellular mechanisms in laboratory animal models.

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Sep 2, 2008 Human Gene Therapy, the Official Journal of the European Society of delivery systems, and animal models, particularly in the areas of

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Jun 3, 2010 Potential side effects of RNAi gene therapy 166. Systemic delivery of siRNAs 166 . In vivo RNAi therapeutic efficacy in animal models of

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by L Zheng - 2010 - Related articlesRNA interference (RNAi) is a posttranscriptional mechanism of gene silencing .. method for preliminary evaluation of siRNA effect in animal models [50], . Izquierdo M: Short interfering RNAs as a tool for cancer gene therapy.

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by LS Reddy - Cited by 1 - Related articlescorrection of neurodegenerative diseases by RNA interference. Gene. Therapy 13: 487–495. Rubinsztein DC (2002). Lessons from animal models of Huntington's

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RNA interference as potential therapy -- not so fast. Article Abstract: RNA interference (RNAi) is successfully used to treat several animal models of human

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by R Kedmi - 2009 - Cited by 1 - Related articlesRNAi nanoparticles in the service of personalized medicine . A candidate for cancer gene therapy: MIP-1α gene transfer to an Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.

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Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery RNA interference (RNAi) gene silencing can be achieved by delivering

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To date there have been no unqualified successes in gene therapy, and biologists study model organisms to learn about how these genes Some plants use RNAi to silence the genes of invading pathogens, and some animals may as well.

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by H HOJO - 2004Gene therapy for hereditary myopathy. Scientific research for engineering animal model of the disease, with RNAi. RNAi induction in C2C12 cell and its

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by A Fjose - 2006 - Cited by 15 - Related articlesAnimals; Disease Models, Animal; Gene Therapy; Humans; MicroRNAs/genetics; MicroRNAs/therapeutic use*; Models, Biological; RNA Interference*. Substances:

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Sep 2, 2009 for cancer gene therapy. HIV-lentivirus-mediated RNAi for Skp-2 resulted in Large animal models of hematopoietic stem cell gene therapy.

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by DE Zamora-Avila - 2007 - Cited by 5 - Related articlesAs a result, our research group is currently working with an animal model of melanoma to test RNAi-mediated WT1 reduction as a potential gene therapy

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by Y Akaneya - 2005 - Cited by 74 - Related articlesIt is possible to use RISLE in establishing animal models of diseases, for example, . RNA interference based gene therapy for neurological disease

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TOC - RNA interference (RNAi) or gene silencing involves the use of double stranded RNA (dsRNA). Use of RNAi to study genes in animal models of diabetes; RNAi for Stem cell-based gene therapy and RNAi for sickle cell disease

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by NJ Caplen - 2004 - Cited by 97 - Related articlesDownregulation of gene expression with RNAi. Most gene therapy approaches have focused on a .. introduced as xenografts into an animal model, signifi-

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by T Hampton - 2004Jun 16, 2004 RNAi is a form of gene silencing that in no way involves the gene itself. so -called essential genes, which cannot be knocked out in animal models problems to overcome before we see RNAi as a therapy," he said.

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by SW Tas - 2009 - Cited by 3 - Related articlesGene therapy in animal models of rheumatoid arthritis: are we ready for the patients? .. Return to the RNAi world: rethinking gene expression

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File Format: PDF/Adobe AcrobatYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by H Xia - 2004 - Cited by 356 - Related articlesneurodegeneration caused by mutant ataxin-1 in a mouse model of SCA1. .. usefulness of RNAi gene therapy for SCA1 and other polyglutamine

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by SL Lin - 2001 - Cited by 35 - Related articlesexpression in higher animal models using D-RNAi, including β-catenin gene knockout in chicken embryos suitable targets for D-RNAi gene therapy, and even

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For example, gene therapy approaches using RNAi and/or ribozymes validity of animal models to predict the impact of novel biotherapeutics in patients.

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Soutschek and colleagues write that RNAi holds considerable promise as a genes in animal models. If so, it should revolutionize the use of RNAi."

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by MD Bobardt - 2003 - Cited by 101 - Related articlesAug 5, 2005 Silencing specific gene expression by RNA interference (RNAi) has rapidly thereby advancing the field of siRNA therapy towards clinical use. by the challenges of siRNA delivery and lack of suitable animal models.

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(For more information on RNAi, please see the links at the end of this article.) While continuing gene therapy research into ways to reduce the damaging

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by R Robinson - Cited by 29 - Related articlesJan 20, 2004 But for all its promise, RNAi therapy is a long way from entering the clinic. . By “knocking down” a gene with RNAi and determining how a cell To date, numerous experiments in animal models suggest RNAi can

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Jun 3, 2010 165 Potential side effects of RNAi gene therapy 166 Systemic delivery of siRNAs 166 In vivo RNAi therapeutic efficacy in animal models

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Apr 15, 2010 Description of an RNAi therapy now entering Phase I clinical trial for disease) that has a single gene inheritance similar to Huntington's (HD). By using this type of RNAi in animal models, scientists in his

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by M Abdelrahim - 2006 - Cited by 5 - Related articlesRNAi is a highly promising technology for gene therapy .. cell culture and animal models has spurred development of RNAi-based reagents for clinical

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Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery of clinically effective delivery systems for DNA and RNAi technologies.

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by A Pfeifer - 2006 - Cited by 56 - Related articles1917) and an age-matched WT animal. (C and G) Analysis of PrPC expression in WT .. We thank Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy . RNAi suppresses polyglutamine-induced neurodegeneration in a model of

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Start reading Gene Silencing by RNA Interference on your Kindle in under a minute Transgenic Animal Models, Academic Press, Axon Instruments, Gene Ther ,

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RNAi technology has gone from proof of principle in animal models to human As a therapeutic model, ddRNAi is analogous to gene therapy with many of

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by A Das - 2009 - Cited by 1 - Related articlesSep 24, 2009 The design of novel anti-HIV vaccination and gene therapy strategies will be presented, including pilot experiments in animal models.

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Feb 24, 2009 MDRNA Successfully Silences Gene Targets In Animal Models Using Novel UsiRNA Constructs MDRNA is well positioned as a leading RNAi therapeutics company and . Hormone Replacement Therapy (HRT), Huntington's Disease

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The discovery of RNAi and siRNA-mediated gene silencing (1) has led to a gene silencing in vivo, in animal models and in RNAi-based therapeutics (4, 5). . Future RNAi therapy will probably be most successful for diseases caused

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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by T Abbas-Terki - 2002 - Cited by 237 - Related articlesmediated RNAi may offer new perspectives in gene therapy for .. RNAi and microRNAs: From animal models to disease therapy.

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Potential side effects of RNAi gene therapy 166. Systemic delivery of siRNAs 166 . In vivo RNAi therapeutic efficacy in animal models of human diseases 167

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by Y Zhang - 2004 - Cited by 176 - Related articlesConclusions: Weekly i.v. nonviral RNAi gene therapy directed against the .. In Vivo Brain Cancer Model. All of the animal procedures were approved by the

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Therapeutic silencing of an endogenous gene by systemic administration of . RNA interference: from model organisms towards therapy for neural and

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Apr 30, 2009 as a drug delivery system has been tested in a number of animal models. Promising Genetic Therapy Uses RNA Interference (Sep.

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by P Gonzalez-Alegre - 2005 - Cited by 46 - Related articlesNov 9, 2005 as demonstrated by reversing pathology in an animal model of lysosomal .. RNA interference based gene therapy for neurological disease

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.animal models. Without PCI: No animals were cured by bleomycin. With PCI: 60% were cured believe that RNAi could significantly change the way in which we go about after gene therapy using PCI as the drug delivery system

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RNAi might be a useful approach in future gene therapy. Promising results have been reported in several animal models55-58 and even in recent clinical

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Oct 7, 2006 RNA Interference Whereas Gene Therapy can be used to introduce new or missing double-stranded RNA into a cell culture or animal model,

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Oct 8, 2008 Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA effective delivery systems for DNA and RNAi technologies.

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by D Grimm - 2007 - Cited by 18 - Related articlesFurther impressive preclinical proof for the vast potential of RNAi gene therapy stems from small animal models of gain-of-function neurodegenerative

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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by Y Zhang - Cited by 175 - Related articlesIn Vivo Brain Cancer Model. All of the animal proce- dures were approved by the University of .. i.v. RNAi gene therapy directed against the human EGFR

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