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by E Charrier - 2006 - Cited by 9 - Related articlesWe generated mice deficient in the CRMP1 gene by homologous chosen to produce chimeric animals by aggregation with morulae of the ICR mouse strain. .. This redundancy could explain the mild phenotype of knockout animals lacking a
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by KS Sugamori - 2003 - Cited by 37 - Related articlesSeveral knockout animal models have already been made for other drug metabolizing enzymes Targeted simultaneous knockout of mouse Nat1 and Nat2 genes by
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.strains utilizing specific gene knockouts have also been shown to affect . in of Zur:ICR mice, Würbel and Stauffacher (1996) found that prevention of a
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by B Rohrer - 2001 - Cited by 13 - Related articlesConclusions from our experiments in knockout mice, however, can be challenged which were outcrossed into an ICR (Institute for Cancer Research) background . .. Although classical gene knockout animals are being used widely,
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Bosma's original work defined leaky animals as those scid mice with Ig Leakiness is absent in ICR scid mice up to 5 months of age, according to Dr.
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by HZ Zhu - 2003 - Cited by 4 - Related articlesMice C57BL/6, ICR mice (clean animal) were purchased from . Le Y, Sauer B. Conditional gene knockout using Cre recombinase.
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The development of a physiologically-relevant mouse model of myocardial infarction is ICR mice can be obtained from Harlan Sprague Dawley (Houston, gene target mice, we generally keep mice in sterile microisolator cages under .. there is increasing interest in using transgenic or knockout mice as a tool
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Knockout animals in which a gene encoding a SASPase has been deleted ( hereinafter, .. obtained by crossing with a mouse with white hair, such as an ICR.
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by AR Cho - 2006 - Cited by 7 - Related articlesney of ICR mice using a DIG-labeled probe. In situ . Tns2 gene in the ICGN mouse, an animal model tion of Tns2-knockout mice. Tns2 deficiency may
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Apr 28, 2010 scrolling mouse crashes windows computer mouse duckie keyboard mouse harnesses mac mouse settings icr mouse gene knockout animal kill mouse
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by GS Lee - 2008 - Cited by 1 - Related articlesAnimals and treatments. Male ICR mice (3 weeks old) were obtained from KOATECH .. EB (2007) A phenotype of a calbindin-D9k gene-knockout is
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Jun 7, 2010 When vitamin C deficient mice, L-gulono-gamma-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by DM Juriloff - 1998 - Cited by 6 - Related articlesSplotch and the Cart1 gene knockout, are discussed. Curly Tail. Curly tail is the best understood mouse model of nonsyndromic spina bifida.
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by T Kumada - 2006 - Cited by 24 - Related articlesSmall pieces of P0–P3 mouse (CD-1) cerebellum were placed on 35 mm a systematic approach with the combined use of gene knockout animals and
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Photo: Lion yawning. icr mouse gene knockout mcleod trail animal hospital. The facts about vivisection (animal experiments), including the case for and
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by Y Terauchi - Cited by 100 - Related articlesknockout mice with disruption of IRS-1 and cell GK genes by crossing the mice with each of the single fect in the development of diabetes, we generated an animal mutants for the GK gene (GK / ) (129 ICR background) (10) were
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by JL Kipp - 2007 - Cited by 29 - Related articlesJan 25, 2007 and ERß-compound knockout mouse models, all of which show . Animal treatment and tissue collection. CD-1 mice (Harlan, . Effect of neonatal DES or E2 treatment on activin subunit gene expression and protein levels
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by JM Sonner - 1999 - Cited by 32 - Related articlesAs a result, the disrupted and wild type genes will be linked to genes from different mouse strains—for the knockout animal, genes derived from the 129
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by L Hou - 2009 - Related articlesIn apoE-/- mice, the peak and the trough of circadian gene mRNA levels were observed All animal experiments were performed according to the criteria of the Medical SCN: suprachiasmatic nucleus; apoE-/-: apolipoprotein E knock- out; on triglyceride contents in the ICR mouse liver under a high-fat diet.
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by KE Tucker - 2001 - Cited by 101 - Related articleslength coilin protein from the knockout animals. Some ho- Mouse 129Sv/J genomic clones containing regions of the coilin gene were
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by A CHATZIGEORGIOU - 2009Mar 1, 2009 Secondly, targeted knock-out studies or specific lymphocyte populations' . NSY mouse comes from the Jc1: ICR mouse, which is also the parental . Thereby , the enzyme is able to remove the gene or exon of interest in
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by M Unno - 2002 - Cited by 50 - Related articlesThe Reg gene disruption resulted in a null mutation. Knockout mice developed Chimeras were subsequently mated to ICR mice for germ-line transmission of the All animals were maintained in a 12-h light/12-h dark photoperiod in a
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by M Kanatsu-Shinohara - 2006 - Cited by 49 - Related articlesHeterozygous mutant mice were intercrossed to produce homozygous gene knockouts. .. Currently, knockout animals are generally produced by microinjection of . The embryos were transferred into the oviducts of ICR pseudopregnant
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by JK Kundu - 2004 - Cited by 35 - Related articlesConversely, knockout of COX-2 resulted in reduced tumor formation Animal treatment. Female ICR mice (6–7 weeks of age) were supplied from the Dae-Han/ Biolink .. regulation of the cyclooxygenase-2 gene by diverse ligands in murine
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by LP Norman - 2003 - Related articlesMeprin [beta] is encoded by a single gene on mouse chromosome 18q12. The meprin [beta] knockout animals that were born did not exhibit overt .. Developmental expression of meprin metalloprotease subunits in ICR and C3H/He mouse
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by JI Mobarakeh - 2006 - Cited by 11 - Related articlesMorphine-induced antinociception in the formalin test in ICR and C57BL/6 mice; 3.6. are enhanced in histamine H1 receptor gene knockout mice (Mobarakeh et al., Animals. Male mutant mice lacking histamine H2 receptors (H2KO mice)
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by W Zhang - 2004 - Cited by 8 - Related articlesAnimal studies. Male and female Cyp1a2-luc transgenic mice at 8–12 weeks of age, 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver. Sequence variation and phylogenetic history of the mouse Ahr gene.
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by KE Tucker - 2001 - Cited by 101 - Related articlesAs described above, coilin knockout animals and cells display extranucleolar Mouse 129Sv/J genomic clones containing regions of the coilin gene were
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by DY Hui - 1998 - Cited by 5 - Related articlesFirst, gene knockout mice can be produced as an animal model for human diseases. . ICR mice to obtain heterozygous and homozygous AGT knockout mice.
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by B Wang - 2001 - Cited by 27 - Related articlesSince the first experimental animal model for CHS was re- years, more than 50 kinds of gene KO mice have been used as .. ICR. FITC. Enhancement
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by J Dong - 2010Genetically engineered mouse mutant models using gene knockout [11], and Use of Laboratory Animals. ICR female mice were bred for timed pregnancies.
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All animal experiments were performed according to the guidelines for animal use We also examined the gene expression profiles in ICR mice during the course .. Azuma C, Murata Y: What knockout mice can tell us about parturition.
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by A et Biotech - 1998 - Cited by 46 - Related articlesWe have been trying to develop an animal model for use in Behçet's amplify the 289-bp region of the HSV genome coding for DNA polymerase, Before using the ICR mouse strain, we tried guinea pig and Further studies will compare the difference between normal and T cell knockout mice inoculated with HSV.
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by LP Norman - 2003 - Cited by 21 - Related articlesThe meprin ß knockout animals that were born did not exhibit overt physical .. subunits in ICR and C3H/He mouse kidney and intestine in the embryo,
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Common examples include CF1, ICR, S and Swiss Webster. of addition of a gene from the animal. These animals are referred to as knockouts. One naturally occurring genetic defect in mice results in an animal with no hair that is
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Single null mutations in mouse genes encoding four male germ cell proteins, . To study the fertility of the triple knockout animals, 10 males and 10
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.ICR-Mouse. Wistar Rat. Sprague Dawley. Rat. Dunkin Hartley. Guinea-pig Thanee Sukglin. 28 Oct. 09. 129 wild type. 129 iNOS(knockout gene)
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Development of Animal Model for Marfan Syndrome through Genetic Manipulations of . Mouse Genome and Analysis of a Knockout Mouse for Fibrillin 1 and Its
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Spontaneous Neoplastic Lesions in the Crl:CD-1® (ICR) BR Mouse in Control Groups . Molecular Phenotyping for Transgenic and Knockout Animals Datasheet
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by K Nayernia - 2003 - Cited by 15 - Related articlesSingle null mutations in mouse genes encoding four male germ cell proteins, . To study the fertility of the triple knockout animals, 10 males and 10
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by D Hernandez - 2009 - Cited by 1 - Related articlesMating of heterozygous knockout mice produced progeny that were heterozygous ( positive for both the human HPRT minigene and the mouse Fmo1 gene) (Fig.
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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Mar 12, 2010 Knockout: congenic name followed by - gene symbol. B6.129P2-Fmr1tm1Cgr/J •80 % of human genes correspond to mouse gene CD-1, Swiss Webster and ICR or NIH Swiss are kept as outbred colonies:
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Female mice to serve as pseudopregnant recipients (ICR ELISA Test Results of the Sentinel Mice. Held in the Transgenic Animal Rooms. Page 24. Gene Knockout in Mice. • 1. Mutant alleles are introduced by homologous
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by I Teppner - 2004 - Related articlesMaterials and methods. Animals. C57BL/6NCrlBR, CFW and ICR mice were .. most commonly used in knockout technology. Mammalian Genome 7, 603–5
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by L Han - 2010 - Cited by 1 - Related articlesOne of the genes regulated by this ICR is the 'cyclin-dependent kinase . A MatDup.dist7 animal and its two littermates at 10 days post-partum is shown ( Figure 4). . This effect was not peculiar to this second knockout allele as
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by DS Lindsay - 1999 - Cited by 164 - Related articlesINF-KO mice were each fed 1 × 104 oocysts. The -INF-KO mice were used because Neither ICR mouse given MPA and N. caninum oocysts died or developed incidental findings due to the random source nature of the experimental animals.
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by C Gentry-Weeks - 2003 - Cited by 6 - Related articlesgene knockout mice had reduced mortality and massive coagulative necrosis was This animal model was chosen because we believed that it approximated .. These studies used CD1 or ICR mouse strains, and with the exception of one
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A knockout non-human animal whose genome comprises a disruption in at least one A tissue of a baby born between the chimeric mouse and ICR was taken.
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by HY Cho - 2002 - Cited by 239 - Related articleswith genetically engineered mice (i.e., gene knockout mice and transgenic mice). . Animals. Breeding pairs of ICR/Sv129-Nrf2 / mice were obtained from a
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by G Vassalli - 1999 - Cited by 31 - Related articlesGene Transfer Into Mouse Carotid Arteries All animal procedures were approved by the .. short-term gene transfer experiments in the arteries of knockout,
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Stock# - 003123 Strain name - 129S;ICR-Vhl /J JAX® Mice Database. Allele Type, Targeted (knock-out). Common Name(s), VHL-; Endothelial function of von Hippel-Lindau tumor suppressor gene: control of Animals Provided. At least two mice that carry the mutation (if it is a mutant strain) will be provided.
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With the development of "knockout" immunodeficient mice, in which genes affecting the . to be virtually devoid of the leaky phenotype, the ICR SCID mouse. . gene knockout animal models further enhances investigators' abilities to
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The American Committee on Laboratory Animal Disease (ACLAD) web site. Throughout the breeding, knockout or transgenic strains genotyped by PCR should for making transgenic mice either are blind (FVB/NJ), or segregate a gene for
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Knockout mice—In these mice a normal mouse gene has been ren- . when attempting to grasp or restrain the animal, as this may cause
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by HS Chang - 2004 - Cited by 49 - Related articlesTransgenic Animals. Fertilized eggs of adult ICR mice (Inbr 29. Albino. .. The phenotype and symptoms of ABCA1 gene knockdown mice. a: The two separate
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by TF Budinger - 1999 - Cited by 68 - Related articlesApplication of the transgenic or gene “knock-out” mouse mutant technology to studies of . Cardiac Blood Pool Dynamics in Small Animals by Planar Imaging
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by K Sakumi - 1997 - Cited by 96 - Related articlesbryos into the uteri of Jcl:MCH (ICR) pseudopregnant females. Chimeric . mice , but there were only a few in MGMT4'@ and MGMT@' animals . TUMORIGENESIS IN MGMT GENE KNOCKOUT MICE action of alkylating agent, O6-methylguanine and 04-
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by S Crotty - 2002 - Cited by 28 - Related articlesNo significant virus titres were detected in any nontransgenic ICR mouse . receptor knockout mice show a massive expansion in the tissue tropism of .. Poliovirus-sensitive transgenic mice as a new animal model. Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice.
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by T Nagase - 1999 - Cited by 2 - Related articlesET-1 gene knockout mice. ET-1 knockout mice were established by gene targeting ( 14). Animal preparation. Animals were anesthetized with pentobarbital sodium . In the present model, we backcrossed the mice to ICR mice to achieve a
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The experimental animal model of human insulin-dependent diabetes mellitus The KO mice exhibited severe diet-induced insulin resistance with reduced Inactivation of this receptor by gene targeting results in mice that develop a
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File Format: PDF/Adobe AcrobatYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by T Saito - 2001 - Cited by 175 - Related articlesby making transgenic animals and using various vector sys- tems. However, the number of characterized .. single pregnant ICR mouse, because there are usually . Subregion- and cell type-restricted gene knockout in mouse brain.
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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by JW Gordon - Cited by 6 - Related articlesa "knockout" mutation) will be designated in accor- Two different gene constructs used for transgenic animal production, either Crl:ICR-TgN(SVDhfr) 432Jwg. The SV40 early promoter driving a mouse dihydrofolate reductase (Dhfr)
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by TJ NelsonFemale KCNJ11 gene knockout mice were treated with reproductive hormones to .. of the KCNJ11 gene-deficient background allowed chimeric animals to be
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by JE Bird - 2000 - Cited by 52 - Related articlesHistopathologic injury was more severe in nephritic CCR2 knockout mice than as the latter requires inhibitors or gene knockout of MCP-1 or its receptor. morula derived from ICR mice in order to generate the CCR2 knockout mice. . of nephritic wild-type mice (E) than CCR2 knockout nephritic animals (F;
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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Apr 28, 2010 Subsequently, the generation of gene knockout or utilizing iPSC to generate gene modified large animals for . electrofusion of 2-cell stage embryos collected from mated female B6D2F1 mice or ICR mice.
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by Y Inokuchi - 2005 - Cited by 20 - Related articlesMay 27, 2010 were backcrossed seven times to the ICR strain. These animals were . angiotensinogen gene knockout mice (Atg2/2) (n = 7) and for TNBS
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by GS Tint - 2006 - Cited by 16 - Related articlesBriefly, mice fed a commercial chow were housed in an animal facility at 22°C .. developmental abnormalities in Wistar rats but not in ICR mice after the ApoB gene knockout in mice results in embryonic lethality in homozygotes
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Mar 16, 2010 The acquisition will enhance SAGE Labs' current rat and mouse breeding rats and mice, including Swiss Webster, Sprague Dawley, ICR, Balb/c, C57BL/6 and Cotton Rats. The group is also developing their catalog of knockout rat next-generation animal research models featuring specific gene
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by JX Zhang - 2010 - Related articlesOct 19, 2009 Established Foxn1 gene knockout mouse models are athymic and T-cell . We used 6 CD-1 (ICR/albino), 6 CD-1 nu, 6 BALB/c, and 6 BALB/c nu male mice as All animal technicians and experimenters were required to wear
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Instead, ICR mouse expressed a 17-kDa AQP5 binding protein that was absent in LGs of SS. In this study we try to determine whether the AQP5 knock-out has some Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse The AQP5 gene is located in human chromosome 12q, the same region as the
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We prefer (C57BL/6J X DBA/2J)F1 animals. Outbred CD-1 and ICR mice can be used, . Most highly repeated dispersed DNA families in the mouse genome. Mol.
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Crl:ICR-TgN(SVDhfr)432Jwg. The SV40 early promoter driving a mouse dihydrofolate reductase (Dhfr) gene; 4 kilobase plasmid; the 32nd animal screened in the
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File Format: PDF/Adobe Acrobat - View as HTMLYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by JA Park - 2010 - Related articlesa knockout mouse experiment (10). Mouse PRDM1 (also known as Blimp1) has been identified as . that PRDM10 has an essential role in regulating gene ex- Animals and mating. Eight week-old ICR mice were obtained from Orient Bio Inc.
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ICR, FVB and C57BL/6 hybrid backgrounds can be produced if investigators are willing . The Microinjection/Mouse Production Core will inject gene-targeted the generation and utilization of transgenic and knock-out animal models.
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by P NUGENT - 1999 - Cited by 15 - Related articlesexpression, i.e. “gene knockout mice” (reviewed in Chambon, 1995). Previous reports with wild-type ICR mice have documented that over The homozygous null animals, in keeping with published reports. (Sucov et al., 1994, 1995;
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by S Kikuchi - 1998 - Cited by 49 - Related articlesSecond, transgenic or gene-knockout mice are now available for The principal aim of the current study was to establish a mouse model of .. In this study, we used the ICR mouse strain for the induction of intimal thickening.
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by P Workman - 2004 - Cited by 59 - Related articlesJan 26, 2004 1e-mail: paul.workman@icr.ac.uk the causal involvement of PI 3-kinase is supported by gene-knockout mouse models. Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models.
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by M Miyamoto - 2006 - Cited by 2 - Related articlesFeb 1, 2010 Normal ICR mice (16 animals) at the same age were used as controls. .. Therefore, the gene responsible for rod dysfunction in IRD1 and IRD2 mice may encode Claes and colleagues reported double knockout mouse
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by SE Hofherr - 2009 - Related articlesstringent mouse model of PCCA deficiency, in which homozygous knockout mice are born but die .. liver-directed gene therapy. When newborn ICR mice were
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by M Gaete - 2004 - Cited by 3 - Related articlestooth formation, even among different animal species, the mechanisms that regulate the number of involving gene targeting can produce a knockout mouse
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by CG Specht - 2001 - Cited by 69 - Related articlesAmplification on brain total RNA of an ICR mouse at P15 with specific α- synuclein Deletion of the α-synuclein gene locus in the BL6JHUK strain. . found to be unaffected by the absence of α-synuclein in the knockout strain BL6JHUK. 14393 (transgenic animal with Snca deletion) arbitrary expression units.
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by Y Feng - 2009 - Cited by 1 - Related articlesNov 17, 2009 The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and role for CIP4 in endocytosis leading to a whole animal phenotype. Mice; Mice, Inbred ICR; Mice, Knockout; Microscopy, Fluorescence
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by DL McCormick - 2004 - Cited by 2 - Related articlesMost transgenic and knockout mouse models were initially developed to address Following the establishment of a causal linkage between the gene and the
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by DA Rees - 2005 - Cited by 121 - Related articlesrodent, mouse, rat, animal model, transgenics, knockout, dia- .. study of cataract development (the JcI-ICR mouse) [55]. Insu- .. Figure 1 Producing transgenic animals that over-express a gene. Gene. Copy number. Phenotype
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Custom design and production services for transgenic and knockout animal models Custom Gene Targeting Programs. The mouse knockin/knockout programs from
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Strain ICR Mouse Embryonic Fibroblasts (MEF) are derived from day 12.5 post coitus and not intended for human or animal diagnostic or therapeutic use.
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by N TAKAHASHI - 1999 - Cited by 40 - Related articlesThe use of zero-copy (gene "knockout") animals generated by gene disruption for .. derived from a C56BL/6/CBA F1 embryo and mated their chimeras to outbred ICR mice. .. A mouse view of hypertension. Hypertension 30:1318 -1324,
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by JL Spearow - 1999 - Cited by 146 - Related articlesEven with the highest E2 dose, CD-1 mice showed only a 30% inhibition of testes weight. . Use of an animal model with a highly resistant genotype to assess . Foxn1 Gene Knockout Suppresses Sexual Attractiveness and Pheromonal
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by C Avivi-Green - 2006 - Cited by 20 - Related articlesThe original line generated in a 129Sv/ICR background has been backcrossed . mice had elevated levels of tenascin-C, whereas knockout animals did not (Figure 2C). .. The use of a DDR1 gene knockout mouse, which avoids the commonly
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by W Shi - 2009 - Related articlesThe aim of this study was to establish an sp3111-knockdown male mouse model for (ICR) mice aged 4–6 weeks were purchased from SIPPR-BK Laboratory Animal Company . The beauty of transgenic RNAi is that, unlike gene knockouts,
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by M Miyamoto - 2006 - Cited by 2 - Related articlesmozygous mutation in the same rod function–related gene, and additionally. IDR1 mice had affected cone systems caused by a to those of transgenic or knockout models.7,8 There- mice at 1 month of age. Normal ICR mice (16 animals)
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by Y Feng - 2010 - Cited by 1 - Related articlesNov 17, 2009 Each clone was expanded, aggregated with ICR morulas, Experiments were performed on 129 mice and approved by the Institutional Animal Care and Use . Generation of CIP4 Knock-out Mice. The murine Cip4 gene consists
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